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hbx19818  (MedChemExpress)


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    Structured Review

    MedChemExpress hbx19818
    Hbx19818, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hbx+19818/HBX+19818/pm39106181-641-20-22
    Average 93 stars, based on 18 article reviews
    hbx19818 - by Bioz Stars, 2026-10
    93/100 stars

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    Related Articles

    Recombinant:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Immunoprecipitation:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Magnetic Beads:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Pull Down Assay:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Western Blot:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Transfection:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    In Vitro:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    shRNA:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Plasmid Preparation:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.

    Modification:

    Article Title: Ubiquitin-specific proteinase 1 stabilizes PRRSV nonstructural protein Nsp1β to promote viral replication by regulating K48 ubiquitination
    Article Snippet: ML323 (HY-17543), PR-619 (HY-13814), USP7-IN-1 (HY-16709), P22077 (HY-13865), P005091 (HY-15667), HBX-19818 (HY-17540), USP7-USP47 inhibitor (HY-13487), DUBs-IN-1 (HY-50736), DUBs-IN-2 (HY-50737A), and DUBs-IN-3 (HY-50737) were purchased from MedChemExpress.



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    circRNA ribosomal protein S19 upregulates HK2 protein via USP7-mediated deubiquitination. (A) Co-IP analysis of the interaction between USP7 and HK2 in AGS cells. (B) Immunofluorescence assay detected the co-localization of USP7 and HK2 in AGS cells. WB of (C) HK2 protein expression in AGS cells and (D) degradation rate of HK2 protein in CHX-treated AGS cells following USP7 ablation and (E) HK2 protein expression following USP7 overexpression and <t>HBX19818</t> treatment in AGS cells. (F) IP showed HK2 ubiquitination in MG132-treated AGS cells following USP7 depletion. * P<0.05, ** P<0.01, *** P<0.001 vs. control group. HK2, hexokinase 2; USP7, ubiquitin-specific processing protease 7; IP, immunoprecipitation; CHX, cycloheximide; HBX19818, a specific inhibitor of USP7; si, small interfering; NC, negative control; WB, western blotting; Ub, ubiquitin.
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    Image Search Results


    circRNA ribosomal protein S19 upregulates HK2 protein via USP7-mediated deubiquitination. (A) Co-IP analysis of the interaction between USP7 and HK2 in AGS cells. (B) Immunofluorescence assay detected the co-localization of USP7 and HK2 in AGS cells. WB of (C) HK2 protein expression in AGS cells and (D) degradation rate of HK2 protein in CHX-treated AGS cells following USP7 ablation and (E) HK2 protein expression following USP7 overexpression and HBX19818 treatment in AGS cells. (F) IP showed HK2 ubiquitination in MG132-treated AGS cells following USP7 depletion. * P<0.05, ** P<0.01, *** P<0.001 vs. control group. HK2, hexokinase 2; USP7, ubiquitin-specific processing protease 7; IP, immunoprecipitation; CHX, cycloheximide; HBX19818, a specific inhibitor of USP7; si, small interfering; NC, negative control; WB, western blotting; Ub, ubiquitin.

    Journal: International Journal of Oncology

    Article Title: circRPS19 affects HK2-mediated aerobic glycolysis and cell viability via the miR-125a-5p/USP7 pathway in gastric cancer

    doi: 10.3892/ijo.2023.5546

    Figure Lengend Snippet: circRNA ribosomal protein S19 upregulates HK2 protein via USP7-mediated deubiquitination. (A) Co-IP analysis of the interaction between USP7 and HK2 in AGS cells. (B) Immunofluorescence assay detected the co-localization of USP7 and HK2 in AGS cells. WB of (C) HK2 protein expression in AGS cells and (D) degradation rate of HK2 protein in CHX-treated AGS cells following USP7 ablation and (E) HK2 protein expression following USP7 overexpression and HBX19818 treatment in AGS cells. (F) IP showed HK2 ubiquitination in MG132-treated AGS cells following USP7 depletion. * P<0.05, ** P<0.01, *** P<0.001 vs. control group. HK2, hexokinase 2; USP7, ubiquitin-specific processing protease 7; IP, immunoprecipitation; CHX, cycloheximide; HBX19818, a specific inhibitor of USP7; si, small interfering; NC, negative control; WB, western blotting; Ub, ubiquitin.

    Article Snippet: To analyze protein stability, GC cells were treated with 5 μ M cycloheximide (CHX, HY-12320, MedChemExpress) for 0, 3, 6, 9 h or treated with 20 μ M MG132 (HY-13259, MedChemExpress) for 4 h. Cells were treated with 10 μ M HBX19818 (HY-17540, MedChemExpress) to inhibit USP7 expression.

    Techniques: Co-Immunoprecipitation Assay, Immunofluorescence, Expressing, Over Expression, Ubiquitin Proteomics, Control, Immunoprecipitation, Negative Control, Western Blot